UniProtKB/Swiss-Prot PTM Description

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis

Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified

Glycosylation Sites

Position Structures Description Evidence
W-319 Associated Structures: 1 global GlycoSuite
Site-Specific Information

A number of glycan structures have been assigned to specific glycosylation sites

Position Structures Description Evidence
TRP-319 Associated Structures: 1 Site specific GlycoSuite

Glycan Structures


Accompanying information

Structure Format

CFG/Essentials Text Oxford



References 1

  1. Recombinant human interleukin-12 is the second example of a C-mannosylated protein.

    Doucey M, Hess D, Blommers M, Hofsteenge J

    PubMed: 10207176 Year: 1999